Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow [redacted] on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.
Job DescriptionAbbVie's Biotherapeutics and Genetic Medicine Protein Science Group is seeking a dedicated and experienced scientist to join our Biomolecular Interaction Team based at AbbVie's Bioresearch Center in Worcester, MA. This position offers a unique opportunity to contribute significantly to various Discovery Research Therapeutic Areas and Projects by providing in-depth analytical and functional characterization of our biopharmaceutical products, such as monoclonal antibodies, multi-specifics, and antibody-like biologics. The ideal candidate will have a strong background in high-throughput biologics screening and characterization techniques (e.g., SPR, BLI, ELISA, FACS) and will foster productive collaborations with other BGM groups and Therapeutic Areas (TAs). This is an excellent opportunity for a motivated scientist to make a significant impact in a collaborative and innovative environment. Join us in bringing innovative medicines to patients!
Key Responsibilities:- Independently develop and execute SPR (Biacore and Carterra platforms) assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics with high productivity levels.
- Evaluate and integrate protein-protein interaction technologies (e.g., SPR, BLI, ELISA, etc.) to support therapeutic candidate selection.
- Implement high-throughput epitope binning for monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.
- Perform antibody Fc characterization studies to support regulatory submissions.
- Identify and resolve technical challenges independently and conceive and implement innovative research approaches.
- Exhibit scientific initiative and creativity in biologics characterization and screening to support BGM and TA projects, such as multi-specifics.
- Analyze, document, and report data concisely, formulate conclusions, and design follow-on experiments based on multidisciplinary data.
- Provide direct mentorship and guidance to junior scientists and team members, fostering their scientific development and growth.
- Provide project updates, analyses, and advice to cross-functional teams and senior management.
- Present original work internally and at scientific conferences; may author or co-author scientific papers or patents.
QualificationsQualifications:- BS or MS or PhD in biology, chemistry, biochemistry or related field with typically 10+ (BS), 8+ (MS) or 0+ (PhD) years of experience.
- Experience with analytical/functional characterization of biologics using Surface Plasmon Resonance (SPR) platforms (e.g., Biacore T200 and 8K, Carterra LSA).
- Demonstrated theoretical and practical understanding of the scientific discipline with the ability to learn and master innovative technologies.
- Broad technical knowledge of various analytical, biophysical, and structural methods, such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc., is a plus.
- Experience of high throughput biologics screening with biochemical, biophysical, and cell-based methods.
- Direct experience with biologics, monoclonal antibodies and/or protein therapeutics is a plus.
- Excellent organizational skills with the capacity to manage multiple projects and tasks simultaneously within timelines.
- Goal-oriented team player with excellent verbal and written communication skills and a strong can-do attitude and can operate effectively in a fast-paced, multi-disciplinary environment.
- Ability to adapt to rapid changes in project priorities and timelines.
Key AbbVie Competencies:- Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
- Learns fast, grasps the "essence" and can change course quickly when indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Additional InformationApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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